DOE: Application to pharmaceutical formulations

 DOE: Application to pharmaceutical formulations (2 credits)
Prof. Maria Cristina Bonferoni
Contents: The first part of the course will consider factorial and screening designs aimed at finding critical variables of methods, processes and formulations. The second part will deal with optimization methods. Response surface designs and mixture designs will be considered to find the region where optimal response can be obtained. Different examples of pharmaceutical applications will be studied. Attention will be paid to the application of DOE in the more recent regulatory approach to the pharmaceutical quality. Some examples will be analyzed with a computer specific software. Learning check: discussion of a report on two case studies.